Premarin UK


What is Premarin?

Premarin is an HRT (hormone replacement therapy) drug for use by women. The active ingredients are conjugated estrogens which are dispensed as oral tablets.

Drug Uses

Premarin is prescribed to treat menopausal symptoms such as vaginal dryness and hot flashes. Premarin is also used to prevent osteoporosis developing in post-menopausal women, and to replace the female hormone, estrogen, in women with ovarian disorders. Premarin can also be used to treat cancer in men and women.

Premarin is used to treat other medical conditions not listed in this information guide.


Premarin must always be used as directed. Do not make adjustments to the dose before speaking to a doctor. Premarin may be taken with or without food at the same time every day. Drink a full glass of water with each dose.

Missed Dose

If you miss a dose, it may be taken when you remember. However, do not take the missed dose near the time of the next scheduled dose. In this case, ignore the missed dose. Never double-up on a dose.

Warnings and Precautions

Do not use Premarin if you are allergic to conjugated estrogens.

Do not use Premarin if you have had any of the following: stroke, blood clot, heart attack, untreated vaginal bleeding, liver problems, or any type of hormone-related cancer (breast or uterine).

Tell your doctor if you have had any of the following: hysterectomy, heart disease, high blood pressure, circulatory problems, a genetic history of stroke, kidney disease, endometriosis, asthma, seizures, diabetes, migraine headaches, under-active thyroid, low or high levels of calcium, high cholesterol, porphyria, lupus, or gall bladder disease.

Before using Premarin, you must give your doctor full details of your medical history and other medications that you use. These include herbal medicines and vitamin supplements. Premarin can react badly with some medications.

Long-term use of Premarin can increase the risk of blood clots or stroke, especially in women who smoke or women who are overweight.

If a woman becomes pregnant while using Premarin, she should immediately contact a doctor because Premarin can harm an unborn fetus. While using Premarin, women should use an effective form of contraception.

Premarin may pass into breast milk so women who are breast-feeding should use this drug with caution, under directions of a doctor.

Possible Side-effects

Call for emergency assistance if any of the following symptoms of allergy occur: difficulty in breathing, hives, or swelling of the lips, tongue, throat or face.

Contact your doctor if any of the following serious side-effects occur: pain in the arm or shoulder, chest pain, sweating, nausea, sudden numbness (especially on one side of the body), confusion, headache, vision problems, speech or balance problems, swelling or pain in the lower leg, migraine headache, abnormal vaginal bleeding, stomach pain or tenderness, memory or concentration problems, breast lump, or swelling of the feet, ankles or hands, or jaundice.

Contact your doctor if any uncomfortable symptoms occur, or persist.


If overdose is suspected, call for emergency assistance immediately. Symptoms of overdose with Premarin can include vaginal bleeding, nausea or vomiting.

Storage instructions

Premarin must be kept away from children and stored in a dry, cool place away from sunlight and moisture.

2018 Premarin UK